None listed
Conditions
Brief summary
Heart operations is frequently accompanied by a degree of inflammation and irregular heart beat.This study aims to determine if the use of a solution containing bicarbonate during heart operations will reduce the amount of inflammation and improve heart rhythm. During heart bypass surgery, patients' circulation is supported by a heart lung machine. During this process, the patient's blood is mixed with around 2 L of fluid. In Brisbane, we have developed a fluid for use during heart surgery. Initial results suggest that it maintains the acid levels in the blood better than the conventionally used fluid. This project is seeking to determine whether the new fluid also improves the overall well being of the patient. If shown to improve the overall well being of the patient, it has the potential to reduce hospital stay and hospital costs.
Interventions
Patients undergoing cardiopulmonarybypass will receive a pump prime of 2 litres of bicarbonate based prime . The bicarbonate based prime has the following composition.(Sodium (Na) 140 mmol/L, Chloride (Cl) 116 mmol/L and bicarbonate 24 mmol/L). The pump flow rates and the membrane oxygenator protocls will be as per standard practice.
Sponsors
Princess Alexandra hospital
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Patients undergoing elective or urgent coronary artery bypass grafting
Exclusion criteria
Re-do cardiac surgery Emergent surgery Renal failure Inability to provide informed consent
Outcome results
None listed