None listed
Conditions
Brief summary
The results of the study will examine the association between performance impairment on a simulated driving task and eye measures of drowsiness, induced by acute sleep loss, alcohol and hypnotic drug administration. These findings will help to determine the validity of eye measures as a countermeasure to fatigue-states, with the aim of reducing sleep-related motor vehicle accidents.
Interventions
Three treatment arms completed in random order by each participant, with treatments separated by at least one week: 1) Single 20mg dose Temazepam administered orally & observed for 5hrs; 2)Orally administered alcohol doses resulting in two peak blood alcohol concentrations (BACs), 0.05% & 0.08%, observed for 8hrs total with 1.5hrs between peak BACs; 3) Restricted sleep (4hrs) observed for 8hrs.
Sponsors
Institute for Breathing and Sleep
Study design
Allocation
Non-randomised trial
Intervention model
Crossover
Primary purpose
Educational / counselling / training
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1) Current Australian driving licence, provisional or unrestricted; 2) Alcohol intake in standard drinks >0 average, <5/day for males and <3/day for females.
Exclusion criteria
1) Epilepsy; 2) Diabetes requiring insulin; 3) Chronic psychiatric illness; 4) Visual impairment which does not correct with glasses; 5) Unable to speak and read English; 6) Drink more than 5 caffeinated beverages per day; 7) Significant daytime sleepiness (Epworth Sleepiness Scale score > 11); 8) Chronic neurological illness; 9) Chronic liver disease, diabetes requiring insulin or renal impairment; 10) Pregnancy or breast feeding; 11) Sleep apnoea, narcolepsy; 12) Use of sedating medication.
Outcome results
None listed