None listed
Conditions
Brief summary
We hypothesised that in the context of weight maintenance and identical macronutrient (e.g. carbohydrate) and fibre intake, the replacement of high GI carbohydrates with low GI carbohydrates would improve acne severity by lowering blood insulin concentrations. We studied adolescent males attending boarding school so that food intakes could be more easily controlled.
Interventions
Adolescent males were alternately allocated to the intervention treatment (low glycemic index (GI) diet) or the comparator treatment (high GI diet) for a period of 8 weeks. Low GI foods included verified low GI brands of muesli and a processed fruit snack, and lasagne (average daily GI of low GI diet intervention was 51). Macronutrient and energy intakes were similar between this intervention group and the comparison group (high GI). Severity of inflammatory lesions on the face, insulin sensi
Adolescent males were alternately allocated to the intervention treatment (low glycemic index (GI) diet) or the comparator treatment (high GI diet) for a period of 8 weeks. Low GI foods included verified low GI brands of muesli and a processed fruit snack, and lasagne (average daily GI of low GI diet intervention was 51). Macronutrient and energy intakes were similar between this intervention group and the comparison group (high GI). Severity of inflammatory lesions on the face, insulin sensitivity (homeostasis modelling assessment of insulin resistance), androgens and insulin-like growth factor-1 and its binding proteins were assessed at baseline and 8 wk, a period corresponding to the school term.
Sponsors
The University of Sydney
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
Male
Age
10 Years to 19 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy adolescent males with acne at a secondary boarding school in Sydney, Australia: acne severity grade 1, 2 or 3, stable weight over the past 3 months and parental/guardian consent.
Exclusion criteria
The previous use of isotretinoin, antibiotics in the past month, excessive alcohol intake, illicit drugs, smoking, physical or mental illness, food allergy or intolerance, vegetarianism, previous surgery on the gastrointestinal system, black skin (due to difficulty in visualising lesions), or final school examinations in the coming months.
Outcome results
None listed