The Australian Ultraviolet Radiation and Immunity Study

Assessing in healthy young Australian adults whether exposure to solar ultraviolet radiation (UVR) at levels relevant to normal daily activities affects immune response to primary vaccination.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12610000234011

Acronym

AusUVI

Enrollment

210

Registered

2010-03-19

Start date

2010-06-15

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study assesses whether exposure to solar ultraviolet radiation at levels relevant to normal daily activities can suppress the immune response to vaccination in young, healthy adults.

Interventions

Participants will wear a ultraviolet radiation (UVR) absorbant wrist band which will measure UVR personal exposure for 5 days. Subsequently all participants will be vaccinated subcutaneously with 125mcg keyhole limpet hemocyanin (KLH) administered to a sun exposed part of the forearm. Participants will be recruited over a 52 week period.

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 18 - 40 years * Healthy * Willing and able to sign informed consent

Exclusion criteria

* Allergy to shellfish * Pregnancy or breastfeeding * Previous KLH vaccination * Immunosuppressive medications * Immunosuppressive medical condition * Recent infection (within 2 weeks of vaccination) * Recent immunisation with any other vaccine in past 4 weeks * Photosensitive skin or taking photosensitsing medication

Outcome results