Pulmonary physiology in obesity

Physiological mechanisms behind the association between asthma and obesity - an observational study measuring airway closure

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12610000226000

Enrollment

105

Registered

2010-03-18

Start date

2010-04-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

There is an association between obesity and asthma. Obesity is thought to increase the risk of developing asthma and also the severity of asthma. The mechanisms behind this association are unclear. The aim of this study is to determine the of obesity on the pattern of ventilation (termed heterogeneity) and of airway closure. We propose that obesity increases closure of airways but improves ventilation patterns, thereby paradoxically protecting against asthmatic airway narrowing (airway hyperresponsiveness).

Interventions

Airway closure as measured by Single Photon Emission Computed Tomography (SPECT) and Computed Tomography (CT) scans scans and closing capacity will be measured. The other tests which will be measured are ventilation heterogeneity and lung volumes. Patients will be seen for two visits, two days apart and recruitment will take place over the next three years.

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

Obesity, body mass index (BMI) > 30 kg/m2 Asthmatics with doctor diagnosed asthma

Exclusion criteria

history of cardiac or respiratory disease,(other than asthma) current (within the last 6 months) or previous smoking >10 pack years

Outcome results