None listed
Conditions
Brief summary
Elderly asthmatics have poorer clinical outcomes compared with younger asthmatics. The reasons for this are unclear but may involve age-related changes in the disease itself. In this project we aim to show that asthma in the elderly is dominated by abnormalities of very small peripheral airways, in contrast to younger patients where the abnormalities occur in larger airways. The results will provide the basis for new and better targeted treatment strategies for asthma in the elderly.
Interventions
The predictors of airway hyperresponsiveness are being measured and compared with other measures of ventilation heterogeneity, lung elastic recoil, airway closure measured by lung imaging and lung volumes.
The study will last for 3 years, however each subject will complete 4 visits over 1-2 weeks.
Sponsors
Woolcock Institute of Medical Research
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
Doctor diagnosed asthmatics
Exclusion criteria
Current smoking or history of smoking > 10 pack years, lung disease other than asthma, taking oral corticosteroids in last 4 weeks or having upper respiratory tract infection in last 4 weeks.
Outcome results
None listed