Comparison of efficacy and cognitive side effects of bifrontal and bitemporal electroconvulsive therapy (ECT) for major depression

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000177055

Enrollment

Registered

2010-02-26

Start date

2000-05-15

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Comparison of efficacy and cognitive side effects of bifrontal and bitemporal ECT for major depression

Interventions

Bifrontal electrode placement, with each electrode placed 5 cm above the outer angle of the orbit on a line parallel to the sagittal plane. Treatment was given with a square-wave, brief-pulse, constant-current device for stimulating a seizure lasting a minimum of 20 seconds going up to a maximum of 60 seconds. It was administred three times a week, until remission or completing twelve treatments.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Major depressive episode in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, with scores > or = 21 in MADRS and > or = 4 in CGI

Exclusion criteria

Prior diagnosis of schizophrenia, schizoaffective disorder, rapid-cycling bipolar disorder, substance dependence, dementia, neuropsychiatric disorders or severe non-psychiatric diseases; ECT treatment in the previous six months

Outcome results