A study assessing the ability of a Manuka honey preparation to treat the symptoms of cold sores when applied topically

A single open-labelled study to assess the safety and performance of a Leptospermum scoparium (Manuka) essential oil preparation for the topical treatment of cold sores

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000163000

Enrollment

Registered

2010-02-19

Start date

2009-06-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of the study is to assess the effectiveness of using a manuka honey topical cream in reducing the duration and symptoms of a cold sore outbreak.

Interventions

Cold sore cream: Actives: Manuka oil 100mg Zinc Oxide 150mg Calendula extract 1:1 156mg Propolis extract 5:1 30mg Excipients: castor oil jojoba oil Olive oil Carnauba wax Candellila wax Mixed Tocopherols Ethanol Cream should be applied topically to the cold sore as soon as signs of it appears and applied every 4 hours. The cream should be used until cold sore resolves which is usually any where between 4

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Experience more than 2 cold sore episodes in the past year

Exclusion criteria

1. Currently pregnant or likely to become pregnant in next 6 months 2. currently breastfeeding 3. participating or have participated in another clinical trial in the last 30 days 4. currently active cancer or had cancer in last 5 years 5. Been diagnosed wiht chronic disease that requires significant pharmaceutical therapy (i.e. diabetes, cardiovascular disease [CVD], stroke) 6. Diagnosed wiht thrombosis and/or currently taking blood thinners such as warfarin or heparin 7. unstable depression and/or being treated for any other psychological condition 8. alcohol or drug-dependency problems 9. The use of a drug/natural therapy (eg Acyclovir / Lauriad) for treating cold sores in within the last 30days.

Outcome results