Acute effects of dietary salt intake on blood vessel function

Acute effects of dietary salt intake on endothelial function in healthy men and women with normal blood pressure

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000124033

Enrollment

Registered

2010-02-05

Start date

2009-11-23

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

A high salt diet can damage the blood vessels so that they are less responsive and expand less to the need for greater blood flow. This may cause the accumulation of fat in the artery and lead to heart disease and strokes. There is research to suggest salt can decrease blood vessel function. We are testing whether a salty meal has any short-term effects on blood vessel function in healthy people. We are doing this because we previously showed a higher than recommended salt intake made blood vessel less responsive after 2 weeks.

Interventions

In a randomised cross-over design, participants will consume a test meal containing 65mmol of sodium or a low salt control meal containing 5mmol sodium on 2 separate study days with a 7 day washout period in between treatments. The test meal will comprise of 100ml of Reduced Salt tomato soup made up with 150mL water with 3.8g of added salt (65mmol NaCl sodium chloride). Participants are asked to consume the test meal over a 5 minute period.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Body Mass Index (BMI) > 18.5 kg/m2 Systolic blood pressure <130mmHg Diastolic blood pressure <90mmHg Weight stable over the past 6 months

Exclusion criteria

Know metabolic disease such as liver or kidney disease Treated hypertension Previous clinical cardiovascular disease Use of non-steroidal anti-inflammatory drugs, folate supplementation or systemic steroids Significant weight loss (>5% body weight) in preceding 6 months Unable to comprehend study protocol

Outcome results