International Sarcoma Kindred Study: Identification of inherited risk in individuals with sarcoma

Identification of inherited risk in individuals with sarcoma to aid in the creation of a research resource consisting of biospecimens and associated data

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12610000120077

Acronym

ISKS

Enrollment

3800

Registered

2010-02-04

Start date

2009-07-08

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to identify inherited risk in individuals with sarcoma to aid in the creation of a research resource consisting of biospecimens and associated data. Who is it for? You may be eligible to join this study if you have been diagnosed with sarcoma. Study details Participants will be identified at key sarcoma clinics, asked to complete a questionnarie and provide biospecimens (blood and tissue). The biospecimens will be stored indefinitely in a tissue bank to be utilised by researchers investigating genetic factors contributing to cancer. Information obtained from the questionnaire will be used to ascertain the family history of cancer and other factors that may contribute to development of the disease. The ongoing nature of the project will enable continual provision of important practical information for clinicians and patients leading to more favourable outcomes. Sarcomas contribute disproportionately to cancer burden in our community, because they affect the young, treatment is costly and prolonged and morbidity and mortality is high. Genetic factors appear important in sarcomas, although they have not been well studied for the adult population. Early detection by identifying those at risk may lead to better prognoses. This project aims to create a vital research resource to enable further study into the genetic factors contributing to the hereditary risk of developing sarcoma.

Interventions

Participants will provide a blood sample (& tissue sample if uncompromised by pre-operative treatment at the time of surgery) and health and epidemiological information once upon enrolment. The study is anticipated to be ongoing.

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

All those diagnosed with sarcoma are eligible for inclusion. Controls must be age matched within 5 years of the proband, be older than or equal to 18 years of age, not have had a cancer diagnosis and not be a blood relative.

Exclusion criteria

Controls must be older than or equal to 18 years of age

Outcome results