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A randomised controlled trial of three forms of psychosocial early intervention for borderline personality disorder in youth.

MOBY: A randomised controlled trial of specialised early intervention with individual Cognitive Analytic Therapy, specialised early intervention without individual psychotherapy, and standard youth mental health care for first-presentation borderline personality disorder in youth.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610000100099
Acronym
Monitoring Outcomes of Borderline personality disorder in Youth (MOBY).
Enrollment
139
Registered
2010-02-01
Start date
2011-03-17
Completion date
2015-09-30
Last updated
2023-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Borderline Personality Disorder (BPD) is a severe mental disorder that arises during adolescence and young adulthood. This study investigates the most effective form of early intervention for young people (15-25 years old) presenting for treatment of BPD for the first time. It is a randomised controlled trial comparing three interventions: two forms of the specialised HYPE early intervention (one with and one without 16 sessions of individual Cognitive Analytic Therapy), along with an intervention of the same duration comprising general youth mental health care. The primary outcomes are improvement in interpersonal problems and social adjustment. It is expected that at the 12- and 18-month time points after enrolment that participants who receive HYPE plus individual Cognitive Analytic Therapy will have better outcomes on these measures than those who receive HYPE without individual Cognitive Analytic Therapy, and that both these groups will have better outcomes than those who receive general youth mental health care.

Interventions

Three interventions will be compared. Two of the interventions are two forms of the Helping Young People Early (HYPE) specialised early intervention for borderline personality disorder. The third intervention is youth mental health care. The three study arms will be: i) HYPE + individual Cognitive Analytic Therapy (HYPE+CAT); ii) HYPE + ‘Befriending’ (HYPE+Bef); iii) Youth mental health care + Befriending (YMH+Bef). HYPE+CAT is an integrated, multidisciplinary team-based early intervention se

Three interventions will be compared. Two of the interventions are two forms of the Helping Young People Early (HYPE) specialised early intervention for borderline personality disorder. The third intervention is youth mental health care. The three study arms will be: i) HYPE + individual Cognitive Analytic Therapy (HYPE+CAT); ii) HYPE + ‘Befriending’ (HYPE+Bef); iii) Youth mental health care + Befriending (YMH+Bef). HYPE+CAT is an integrated, multidisciplinary team-based early intervention service model for borderline personality disorder. It uses a shared psychosocial model of borderline personality disorder and a common language for communication with patients, families and carers, team members and the wider service system. HYPE+CAT includes: i) rigorous diagnosis of BPD and other personality pathology; ii) up to 16 x 50-minute individual Cognitive Analytic Therapy (CAT) sessions delivered over approximately 26 weeks; iii) assertive case management integrated with the delivery of psychotherapy; iv) developing a collaborative model of the individual patient’s difficulties that is shared with the patient, HYPE team, family and relevant others and is used for intra- and extra-service liaison; v) active engagement of families or carers, with psychoeducation and up to four sessions of family intervention; vi) general psychiatric care, with specific assessment and treatment of co-occurring psychiatric syndromes (‘comorbidity’), including the use of pharmacotherapy (where indicated), while minimising polypharmacy; vii) access to the shared elements of Orygen Youth Health – crisis team, inpatient care, activity group program; viii) with a clear model of brief and goal-directed crisis and inpatient care; ix) individual and group supervision of staff; and x) a quality assurance program. HYPE+Bef will comprise all of the elements of HYPE+CAT except that ‘individual Cognitive Analytic Therapy’ will be substituted with up to 16 x 50-minute individual sessions of ‘Befriending’ delivered over approximately 26 weeks. Befriending is a manualised intervention that consists of talking about neutral topics that interest the participant (e.g. music, sport, books). If the participant finds verbal interaction difficult, activities such as board games, walking, or playing sport, can be used with a view to using the activity as a tool to engage the participant in further neutral conversation during and after the activity. The therapist’s primary goals are to keep the participant engaged for the full duration of therapy and to keep the conversation or activity as close to a neutral ‘pleasant chat’ as possible.

Sponsors

National Health and Medical Research Council
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
15 Years to 25 Years
Healthy volunteers
No

Inclusion criteria

Broad inclusion criteria to capture the "real world" clincial environment. These are: (1) Age 15-25 inclusive, (2) Ability to give informed consent and comply with study procedures, (3) Fluency in English, (4) Structured Clinical Interview for DSM-IV axis II disorders BPD.

Exclusion criteria

(1) First episode psychosis within the 12 months prior to entering the study, (2) Structured Clinical Interview for DSM-IV Axis 1 Bipolar I or II Disorder, (3) Psychiatric condition due to a medical condition, (4) Severe disturbance, such that the person is unable to comply with the requirements of informed consent or the protocol, (5) A Schizophrenia Spectrum Disorder, (6) prior evidence-based BPD treatment, (7) does not meet the clinical services' eligibility criteria (e.g. catchment area).

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 4, 2026