None listed
Conditions
Brief summary
This study has been designed to investigate the efficacy of short wavelength enriched light exposure as a therapeutic intervention for the adverse neurobehavioural consequences of sleep loss and circadian rhythm disruption in night shift workers, and to examine retrospectively whether individual differences in responsiveness to light can be predicted by circadian phase estimates and genetic differences. The study will be carried out at three different sites, these include (1) Monash University, (2) The University of Sydney and (3) University of South Australia.
Interventions
Participants will be exposed to High Colour Temperature Light (HCT; 17,000K, 200 lux) administered using Philips EnergyLight HF3309 lamps or a panel of Light Emitting Diodes.
Participants will visit a light controlled, sound attenuated, temperature controlled laboratory from 6:00pm to 8:30am. Exposure to the light will occur in one intervention from 11:00pm to 7:00am. During the light exposure participants will be required to stay awake and complete computer or paper based assessments of their
Participants will be exposed to High Colour Temperature Light (HCT; 17,000K, 200 lux) administered using Philips EnergyLight HF3309 lamps or a panel of Light Emitting Diodes. Participants will visit a light controlled, sound attenuated, temperature controlled laboratory from 6:00pm to 8:30am. Exposure to the light will occur in one intervention from 11:00pm to 7:00am. During the light exposure participants will be required to stay awake and complete computer or paper based assessments of their mood and performance, while seated. The rest of the time participants will be allowed to do quiet tasks such as reading, puzzles or card games.
Sponsors
Monash University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
(1) Male and female adults aged 18 to 65 years inclusive. (2) Healthy. (3) Engaged in 5 or more night shifts per month.
Exclusion criteria
(1) Individuals who report high caffeine, nicotine and/or alcohol intake. (2) Individuals who screen positive for drugs of abuse following comprehensive urine toxicological analysis. (3) Women who are pregnant, lactating or planning to become pregnant during the study period. (4) A history of alcohol/drug dependence. (5) Current, recent (<3 months) or chronic history of use of drugs or medication that affect the central nervous system (except non-steroid topical creams, oral contraceptives and occasional use of mild pain killers). (6) History of psychiatric illness on the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM IV Axis 1). (7) History of cardiovascular disease. (8) Abnormal sleep patterns/sleep disorders. (9) Auditory defects (accepted if corrected with hearing aids). (10) Any form of photophobia including drug-induced, epilepsy, seizures, vertigo or migraine. (12) Individuals with diseases of the visual system. (13) Females who are not taking a medically approved form of birth control.
Outcome results
None listed