Nambour Community-based Skin Cancer Prevention Trial

Community-based trial of daily versus usual sunscreen use and beta-carotene versus placebo supplements to prevent skin cancer

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000086066

Enrollment

1625

Registered

2010-01-27

Start date

1992-02-01

Completion date

1992-03-15

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

A randomised trial was conducted to assess whether daily application of a sun protection factor (SPF) 15+ sunscreen to the head, neck, arms and hands, or beta-carotene supplementation (30 mg/day) would prevent skin cancers and related tumours and premature skin ageing in comparison with discretionary use of sunscreen or a daily placebo supplement. The The hypothesis was that regular sunscreen use by adult Caucasians prevents the occurrence of skin cancers and related sun-related degenerative skin conditions

Interventions

"Daily sunscreen, Beta-carotene supplements" Daily sunscreen: (Sun Protection Factor (SPF) 15+, to be applied to head, neck, arms and hands every morning (and to reapply after heavy sweating, bathing, or long sun exposure), for 5 years. Beta-carotene supplements: 30mg once daily as oral capsule, for 5 years. 4 arms in trial viz. Arm 1: daily sunscreen, beta-carotene supplements Arm 2: daily sunscreen, placebo supplements Arm 3: beta-carotene supplements, discretionary sunscreen Arm 4: discret

Study design

Allocation

Randomised controlled trial

Intervention model

Factorial

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 76 Years

Healthy volunteers

Yes

Inclusion criteria

Registered on the state electoral roll for Nambour in Nov 1986

Exclusion criteria

Lack of signed consent

Outcome results