The effect of propofol on emergence delirium in children after sevoflurane anaesthesia

The effect of propofol on emergence delirium in children after sevoflurane anaesthesia for magnetic resonance imaging (MRI). A randomized controlled trial.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000025033

Enrollment

250

Registered

2010-01-08

Start date

2010-01-12

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

After anaesthesia children frquently become irritable and distressed. This is termed Emergence Delirium (ED). Sometimes this can lead to intravenous lines and surgical drains becoming dislodged. The child rarely remember this period and it rarely has any longterm consequences. A number of studies have suggested that a commonly used anaesthetic drug called propofol can be used to reduce the chance of this happening. We plan to administer a dose of propofol at the end of an anaesthetic to see whether it will reduce the rate of ED.

Interventions

We wish to examine whether administration of intravenous propofol 3mg/kg over 3 minutes at the end of a sevoflurane anaesthetic can reduce the incidence of emergence delirium in children.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

1 Years to 12 Years

Healthy volunteers

Inclusion criteria

Children listed for Magnetic Resonance Imaging under general anaesthesia.

Exclusion criteria

Allergy to propofol or egg product. History of Malignant Hyperpyrexia. Any child due to also undergo a painful procedure or one requiring pupil dilatation.

Outcome results