None listed
Conditions
Brief summary
Compared to other currently available inhalational anaesthetics, desflurane is less soluble. Consequently, its rapid elimination from the brain is expected to result in an improved postoperative recovery profile. However, desflurane is more expensive to administer than other inhalational anaesthetics. Isoflurane is a commonly used inhaled volatile anaesthetic because it is relatively inexpensive despite its high solubility. To combine the advantages of rapid emergence from desflurane anaesthesia with the lower cost of a more soluble inhalation anaesthetic, we substitute desflurane with isoflurane during the latter part of anaesthesia and compare the emergence and recovery characteristic with pure desflurane and pure isoflurane anesthesia. We hypothesize the substitution from isoflurane to desflurane during the latter part of anesthesia improve recovery and emergence characteristics.
Interventions
inhaled anaesthesia was maintained with 1.2-2.4 vol% of isoflurane depending on the vital sign to the point when the operation was predicted to end in an hour; subsequently, isoflurane was replaced with 1 minimum alveolar concentration (MAC) of inhaled desflurane (1 MAC of desflurane = 6 vol%) in 1.5 L/min oxygen (O2) and 1.5 L/min nitrous oxide (N2O)
Sponsors
Chung-Ang University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
patients undergoing laparotomy expected to lasting 3 or more hours under general anaesthesia
Exclusion criteria
Patients with clinically significant pulmonary, cardiovascular, hepatic, renal, hematologic, neurologic, or metabolic diseases and those who were chronic users of drugs that are known to affect anaesthetic requirements
Outcome results
None listed