None listed
Conditions
Brief summary
This study will compare the effects of common "lifestyle" factors of sleep loss and alcohol on driving simulator performance in patients with obstructive sleep apnoea and healthy subjects and evaluate the effectiveness of continuous positive air-way pressure treatment in improving driving simulator performance
Interventions
Initial baseline evaluation of driving simulator performance will be performed in patients with obstructive sleep apnoea and matched healthy subjects under three conditions of normal sleep, restricted sleep (4 hrs) and alcohol (0.05 g/dL) in a random order one week apart. Patients will then undergo a laboratory based countinuous positive air-way pressure (CPAP) titration study, issued a CPAP machine and encouraged to use it as much as possibe but at least 4 hours per night for a minimum of 3 mon
Initial baseline evaluation of driving simulator performance will be performed in patients with obstructive sleep apnoea and matched healthy subjects under three conditions of normal sleep, restricted sleep (4 hrs) and alcohol (0.05 g/dL) in a random order one week apart. Patients will then undergo a laboratory based countinuous positive air-way pressure (CPAP) titration study, issued a CPAP machine and encouraged to use it as much as possibe but at least 4 hours per night for a minimum of 3 month. Control subjects were not on any treatment and were asked to continue their normal activities.
Sponsors
National Health and Medical Research Council
Study design
Allocation
Non-randomised trial
Primary purpose
Educational / counselling / training
Eligibility
Sex/Gender
All
Age
25 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Aged 25-70 years At least 2 OSA symptoms (snoring, choking arousals or witnessed apneas, excessive daytime sleepiness) Full Diagnostic polysomnogram showing an apnea/hypopnea index >15 events/hr, central apnea index <5/hr untreated for OSA Live in Adelaide (not country patients) Full private standard driving license, drive at least 2 hours per week and have been driving in Australia for at least 2 years.
Exclusion criteria
History of significant head injury History of alcohol or drug abuse History of central nervous system disease (e.g. past history of stroke) Current use of medication which may affect driving (e.g. sedating antihistamines and opiates, regular use of hypnotics and other sedating psychotropic or anticonvulsant medication) Sleep disorders such as narcolepsy, periodic limb movement disorder, restless legs syndrome, insomnia Significant medical co-morbidities likely to affect sleep (e.g. severe chronic obstructive pulmonary disease (COPD) with forced expiratory volume in the first second (FEV1) <50%, significant cardiac failure (New York Heart Association [NYHA] 3 or 4), major depression). Professional drivers Night shiftworkers
Outcome results
None listed