None listed
Conditions
Brief summary
Baseline mucociliary and cough clearance is very abnormal in asthmatics with excessive secretions and presenting symptoms of chronic cough and sputum production. Inhaled mannitol markedly improves mucociliary clearance and this effect is dose dependent in the large airways. Repetitive voluntary coughing following inhalation of mannitol enhances clearance of mucus. Asthmatics with mucociliary dysfunction, after careful assessement and appropriate premedication may benefit from inhaling mannitol to clear excessive secretions and prevent mucus plug formation in the small airways
Interventions
The study consisted of 5 visits. The first visit was a screening visit involving assessment of lung function and a bronchial challenge with mannitol after premedication with eformoterol. Subjects were eligible to proceed to the next visits if they had a fall in forced expiratory volume in one second (FEV1) less than 15 % from the baseline value.
Visits 2-5 were mucociliary and cough clearance studies using a radioaerosol technique and imaging with a gamma camera in the Departmet of Nuclear
The study consisted of 5 visits. The first visit was a screening visit involving assessment of lung function and a bronchial challenge with mannitol after premedication with eformoterol. Subjects were eligible to proceed to the next visits if they had a fall in forced expiratory volume in one second (FEV1) less than 15 % from the baseline value. Visits 2-5 were mucociliary and cough clearance studies using a radioaerosol technique and imaging with a gamma camera in the Departmet of Nuclear Medicine. The radioaerosol inhaled was sulphur colloid tagged with technetium. Mucocilairy and cough clearance was measured over a total of 90 min at baseline (no cough or mannitol) and in response to 2 doses of inhaled dry powder mannitol (240 and 480 mg). Patients were premedicated with eformoterol at all times prior to inhaling mannitol. The baseline and mannitol visits were randomised. The last visit was a cough control day involving cough but no mannitol. Cough clearance was assessed by asking the subjects to cough, 30 minutes after mannitol inhalation, 100 times (4 per min) over 30 minutes.
Sponsors
Dr Evangelia Daviskas
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
17 Years to No maximum
Healthy volunteers
No
Inclusion criteria
asthma chronic cough and sputum production
Exclusion criteria
fall in FEV1 greater or equal to 15% in response to mannitol bronchiectasis based on high resolution computed tomography (HRCT)
Outcome results
None listed