Does Picking Intracytoplasmic Sperm Injection (PICSI) improve clinical pregnancy rates in men with elevated deoxyribonucleic acid fragmentation index(DFI) undertaking intracytoplasmic sperm injection (ICSI )treatment for infertility? A randomised pilot study.

Does Picking Intracytoplasmic Sperm Injection (PICSI) improve clinical pregnancy rates in men with elevated deoxyribonucleic acid fragmentation index (DFI) undertaking intracytoplasmic sperm injection (ICSI) treatment for infertility? A randomised pilot study.

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609001065280

Acronym

PICSI vs ICSI

Enrollment

150

Registered

2009-12-11

Start date

2010-02-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Intracytoplasmic sperm injection is commonly used to aid fertilisation rates in men with low sperm counts , poor sperm mobility and high levels of sperm DNA fragmentation. The sperm used to inject into the egg is hand picked by the scientist, based on sperm appearance. However, a scientist is unable to detect poor DNA based on sperm appearance. The PICSI dish contains a substance called hyaluronan that normally exists around an egg. It is proposed that sperm with lower levels of DNA damage are more likely to bind to this hyaluronan. This allows the scientists to be more selective in the handpicking process. By handpicking only that sperm that has bound to the substance, they may be selecting the better sperm for injection into the egg.

Interventions

PICSI - a type of fertilisation technique which allows mature sperm to bind to a substance (hyaluronan) in a dish. Scientists then pick a sperm for use in ICSI from this select population of sperm. Selection is based on morphology and motility. This intervention process takes 5-10 minutes.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

0 to 45 Years

Healthy volunteers

Yes

Inclusion criteria

All couples eligible for (intracytoplasmic sperm injection) ICSI

Exclusion criteria

Men not eligible for Pick Intracytoplasmic Sperm Injection (PICSI) Where the women is older than 43 years of age

Outcome results