Real-time humidity measurements of expired breathe in non-invasive ventilation.

Randomised, cross-over comparison of humidifying load imposed on the human airway under different conditions of inspired gas in a noninvasive setting.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609001055291

Enrollment

Registered

2009-12-10

Start date

2008-11-06

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study is to evaluate the humidifying load imposed on the human airway by inspired gas at various temperatures and humidities. The humidity response of the volunteers are measured in real-time using the infrared laser hygrometer developed by Fisher & Paykel Healthcare Ltd. (FPH).

Interventions

12 different conditions of inspired air (treatments) will be supplied to the volunteers ranging from dry air at room temperature to saturated air at 40 degC. Each participant will receive all the treatments in a randomised order. Different conditions are: 1. 25 degC and 0% Relative Humidity (RH) 2. 25 degC and 100% RH 3. 28 degC and 100% RH 4. 32 degC and 0% RH 5. 32 degC and 100% RH 6. 37 degC and 0% RH 7. 37 degC and 50% RH 8. 37 degC and 100% RH 9. 40 degC and 0% RH 10. 40 degC and 50% RH 11. 40 degC and 100% RH For each of the gas condition, the volunteers are asked to breathe with three different rates that are controlled by a digital blinker written in LabVIEW and a stop watch. Humidity output between oral and nasal breathing will also be studied. Each treatment will last 30 minutes and includes all 3 respiratory rates on both oral and nasal breathing. 24 hours recovering period are given between each treatment. The study will run for 2 months and there will be no follow-up on the participants.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Educational / counselling / training

Masking

Open (masking not used)

Eligibility

Sex/Gender

Male

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

Volunteers must be consenting healthy males.

Exclusion criteria

Cystic fibrosis or respiratory disease.

Outcome results