The influence of surgery on sevoflurane brain levels and awakening after anaesthesia.

To investigate the relationship between the invasiveness of surgery and the point at which patients awaken after anaesthesia and surgery.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12609001050246

Acronym

SW Study

Enrollment

105

Registered

2009-12-08

Start date

2009-05-07

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Previous audit data has suggested the magnitude of surgery has an influence on calculated effect site sevoflurane levels at awakening. The aim of this study is to evaluate this difference using a structured anaesthetic technique so as to minimise confounding variables. As intrathecal morphine (ITM) has become a common adjunct in major surgery we are also exploring the effect of ITM on effect site sevoflurane

Interventions

major bowel surgery and "simple" laparoscopic surgery -determining time of first-response after surgery, pain scores in Post Anaesthetic Care Unit (PACU), time to reach PACU discharge criteria, recovery score. Observed, when possible, up to 48 or 76 hrs post-surgery.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

Non-emergency surgery American Society of Anesthetists (ASA) 1, 2 or 3 Body Mass Index (BMI) less than 35

Exclusion criteria

Contra-indication to propofol. Contra-indication to sevoflurane. Contra-indication to fentanyl.

Outcome results