Remote ischaemic preconditioning in patients undergoing surgery for fractured neck of femur.

Remote ischaemic preconditioning for patients over 65 with fractured neck of femur as a technique to reduce peri-operative myocardial damage, determined by blood troponin markers.

Status

Withdrawn

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609001044213

Enrollment

140

Registered

2009-12-07

Start date

2010-07-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will evaluate an innovative technique which may reduce the chance of older patients suffering heart attacks that occur around the time of surgery. A technique called ‘remote ischaemic preconditioning’ will be used. This involves placing a special blood pressure cuff on the patient’s arm. After anaesthesia but before surgery starts, the cuff will inflate and deflate, briefly interrupting the blood supply. This process releases chemical ‘warning signals’ to the heart, making it less vulnerable to damage during a subsequent heart attack. During a heart attack, heart muscle becomes damaged. Blood tests can measure how much heart muscle has been damaged. The success of the effects of remote ischaemic preconditioning will be measured by using these blood tests of heart damage.

Interventions

Intervention: Remote Ischaemic Preconditioning. This will be applied to the non dominant arm (wherever possible) using an arterial tourniquet at a pressure of systolic blood pressure +40mmHg. The periods of ischaemia will be 5 minutes long, followed by a 5 minute 'washout' or 'rest' period. There will be a total of 3 such ischaemic cycles. Patients assigned to this group will recieve 3 identical cycles as described above. The study design has 2 parallel groups, so participants in this group

Study design

Allocation

Randomised controlled trial

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients (male / female, all ethnic groups) >65yrs who present to Middlemore Hospital with a fractured neck of femur

Exclusion criteria

Patients will be excluded if: They do not consent, or are unable to consent to take part in the study. They are already participating in another clinical trial. Patients present with a second fracture and have previously been recruited to the study. Patients have elevated pre-operative serum troponin I levels. Patients are taking cyclsporin or K+ channel agents

Outcome results