None listed
Conditions
Brief summary
Acetylcholine levels are decreased in delirium, a condition of a sudden change in mental capacity occurring due to a illness, medication or similar insult. Rivastigmine is a medication for Alzhiemer's Disease, another condition where there is a change in mental capacity and low levels of acetylcholine. It increases levels of acetylcholine in the brain. THis trial aims to determine if a rivastigmine patch given to elderly patients in hospital after their illness has resolved but who still have delirium will have a less severe delirium.
Interventions
Transdermal Rivastigmine 4.6mg/hour patch applied topically changed daily for two weeks.
Sponsors
Melbourne Health
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Severe Delirium (Confusion assessment method positive, delirium rating scale 12 or more)
Exclusion criteria
Informed consent unable to be obtained Deficits in cardiac conducting system, resting pulse <50, intolerance or allergy to rivastigmine, carbamates or excipients. Severe dysphasia, visual or hearing impairment, or non english speaking such that unable to complete scales. Expected prognosis or discharge less than 2 weeks.
Outcome results
None listed