None listed
Conditions
Brief summary
Patients from Royal Perth hospital with gout of the knee will be asked to have some blood tests, an ultrasound examination of their knee and fluid withdrawn from the knee to look for evidence of kallikren kinin proteins involved in inflammation.
Interventions
Patients from Royal Perth hospital with gout of the knee will be asked to have some blood tests, an ultrasound examination of their knee and fluid withdrawn from the knee to look for evidence of kallikren kinin proteins involved in inflammation. The study is an observational cross sectional study observing disease activity ( as assessed by symptoms and ultrasound) and kinin metabolism at one time point, although recruitment is likely to take 12 months; nil intervention
Sponsors
Royal Perth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
*Gout of the knee *Aged more than 18 years *Able to provide written informed consent
Exclusion criteria
*Contraindication or unwillingness to undergo an Ultrasound scan *Contraindication or unwillingness to undergo arthrocentesis (including an International normalised ratio greater than 2.0 in subjects on warfarin, or patients on therapeutic dose heparin/ Low molecular weight heparin) *Diagnosis of septic arthritis, other inflammatory joint disease, gout, recurrent episodes of pseudogout, Paget’s disease, articular fracture, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, primary osteochondrosis *injury to the study knee within 6 months of the study start *knee joint replacement (partial or total); osteotomy of the studied joint; with arthroscopy of the studied joint made within 1 year of the study start *With an intra articular injection of steroids made within 4 weeks and/or intra articular injection of radionuclide made with 3 months prior to study entry
Outcome results
None listed