None listed
Conditions
Brief summary
Patients from Royal Perth hospital with osteoarthritis of the knee will be asked to have some blood tests, an ultrasound examination of their knee and fluid withdrawn from the knee to look for evidence of kallikren kinin proteins involved in inflammation.
Interventions
Patients from Royal Perth hospital with osteoarthritis of the knee will be asked to have some blood tests, an ultrasound examination of their knee and fluid withdrawn from the knee to look for evidence of kallikren kinin proteins involved in inflammation. Consenting participants will undergo a single examination incorporating these tests over a duration of approximately 1 hour.
Sponsors
Royal Perth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
*primary knee osteoarthritis (OA), which has been diagnosed based on clinical and radiographic criteria, according to the American College of Rheumatology(knee pain,either age > 50 or morning stiffness < 30 mins or crepitus, osteophytes) *With radiographic evidence of OA for the studied knee based on retrospective bilateral radiography (within last 12 months): Anterior-posterior view in extension and weight bearing position and “sky-line view”; radiographic changes defined by Kellgren-Lawrence score (I to V) *Moderately severe symptoms (> or =40/100 on pain Visual Analogue Scale) *Aged more than 18 years *Able to provide written informed consent
Exclusion criteria
*Contraindication or unwillingness to undergo an Ultrasound scan *Contraindication or unwillingness to undergo arthrocentesis(including an International normalised ratio greater than 2.0 in subjects on warfarin, or patients on therapeutic dose heparin/ Low Molecular Weight heparin) *Diagnosis of septic arthritis, inflammatory joint disease, gout, recurrent episodes of pseudogout, Paget’s disease, articular fracture, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, primary osteochondrosis *With secondary OA, as defined by The Group for the Respect of Ethics and Excellence in Science: septic arthritis, inflammatory joint disease, gout, recurrent episodes of pseudogout, Paget’s disease, articular fracture, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, primary osteochondrosis *With injury to the study knee within 6 months of the study start *With a knee joint replacement (partial or total); osteotomy of the studied joint; with arthroscopy of the studied joint made within 1 year of the study start *With an intra articular injection of steroids made within 4 weeks and/or intra articular injection of radionuclide made with 3 months prior to study entry
Outcome results
None listed