None listed
Conditions
Brief summary
This study will investigate a possible therapeutic strategy to modify diet-induced airway inflammation by the use of statins. The regular intake of high fat food directly causes systemic inflammation. This systemic inflammation may lead to asthma or contribute to increased airway inflammation seen in asthma. Statins are a widely prescribed class of cholesterol lowering drugs indicated for the prevention of cardiovascular disease. They have also be shown to reduce or inhibit inflammatory markers (C-Reactive Protein CRP, IL-6) and cytokines associated with innate immunity (Tumor Necrosis Factor-alpha TNF-alpha, Interleukin-8 IL-8). We propose that statins, which suppress the innate immune response, will suppress the neutrophilic inflammation that we expect as a consequence of a high fat diet. Hypothesis: A high fat diet causes an increase in neutrophilic airway inflammation. Statins will protect against fat-induced inflammation in asthma.
Interventions
High fat challenge before and after Oral Simvastatin 40mg (1 tablet daily for 1 month)
Sponsors
Prof Lisa Wood
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Stable asthma (with or without neutrophilic asthma) Body Mass Index (BMI) < 30
Exclusion criteria
Current smokers, Currently taking lipid lowering drugs or drugs that interact with statins. Subjects with active liver disease, renal impairment, cardiovascular disease, pregnant or breastfeeding
Outcome results
None listed