None listed
Conditions
Brief summary
This study will investigate whether ‘remote ischaemic preconditioning’ (RIPC) decreases complications after high risk cardiac surgery. RIPC involves 3 five minute cycles of ischaemia and reperfusion to an arm applied prior to being put on the heart lung machine for heart surgery. The ischaemia involves inflation of a blood pressure cuff to a level that prevents blood flow to the arm beyond it. Reperfusion involves releasing the blood pressure cuff. While on the heart-lung machine, the heart, lungs and abdominal organs receive less blood supply than normal. There is evidence that RIPC prior to going on the heart-lung machine protects the heart from the decreased blood supply during heart surgery. We are performing this trial to test whether RIPC decreases the risk of heart, lung, kidney and bleeding complications after cardiac surgery.
Interventions
A blood pressure cuff will be inflated to 200mmHg on an upper limb for five minutes and then deflated for five minutes. This cycle will be repeated three times. The intervention will be performed after induction of anaesthesia prior to onset of cardiopulmonary bypass
Sponsors
Paul Young
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patient undergoing high risk cardiac surgery defined as: (i) Bentall’s procedure (ii) Double or triple valve (iii) mitral valve replacement (iv) coronary artery bypass graft (CABG) + valve replacement (v) CABG with ejection fraction<50% (vi) Any redo operation
Exclusion criteria
peripheral vascular disease affecting the upper limbs
Outcome results
None listed