None listed
Conditions
Brief summary
The up-take (bio-availability) of carotenoids is not well understood and conventional methods (plasma anlayses) of determining up take is open to interpretation errors. This pilot study is aimed at assessing the ileostomy model as a model for estimation of bioavailability of nutrients from plant based foods.
Interventions
Participants consume a basal diet low in natural carotenoids throughout the 4 days trial period of each week( Monday to Thursday) and on test days consume one of the 4 test foods (carrot soup). There are 2 control days and 2 test food days on 2 consecutive weeks Participants are required to follow the low carotenoid basal diet for a period of 4 days each week for 2 consecutive weeks. This diet is supplied by CSIRO from specially selected foods to restrict the intake of carotenoid containing foods such as carrots, oranges and tomatoes to a daily dose of <650ug. For each of the test foods the participants will be required to eat a single 300mL serve of the carrot soup containing ~15 mg carotenoids along with 2 slices of white bread and 10g of butter. There will be a 3 day wash-out period between trial periods (from Friday one week to Monday the following week). In each week each participant would randomly have 2 of the test foods on any of the 4 days within that week. The remaining 2 days are control days during which the participants consume only the basal diet with low carotenoids as supplied by CSIRO. During the following week the participants would be required to have the remaining 2 test foods on randomly selected days with the 2 remaining days being control days as described above.
Sponsors
Study design
Eligibility
Inclusion criteria
conventional and well-functioning permanent ileostomy
Exclusion criteria
Use of any form of drug therapy or medication or supplements that may interfere with bowel function eg antibiotics Definite or suspected personal history or family history of adverse events or intolerance of plant-based foods being tested in this study Persons considered by the investigator to be unwilling, unlikely or unable to comprehend or comply withthe study protocol and restrictions Persons unwilling or unable to collect ileal effluent as required Paticipants taking any supplements which could interfere with study parameters