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The potential of food processing technologies to improve bioavailability of carotenoids from carrots-a pilot study in volunteers with ileostomy

The potential of food processing technologies to improve bioavailability of carotenoids from carrots-a pilot study in volunteers with ileostomy

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12609000947202
Enrollment
8
Registered
2009-11-04
Start date
2009-11-23
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The up-take (bio-availability) of carotenoids is not well understood and conventional methods (plasma anlayses) of determining up take is open to interpretation errors. This pilot study is aimed at assessing the ileostomy model as a model for estimation of bioavailability of nutrients from plant based foods.

Interventions

Participants consume a basal diet low in natural carotenoids throughout the 4 days trial period of each week( Monday to Thursday) and on test days consume one of the 4 test foods (carrot soup). There are 2 control days and 2 test food days on 2 consecutive weeks Participants are required to follow the low carotenoid basal diet for a period of 4 days each week for 2 consecutive weeks. This diet is supplied by CSIRO from specially selected foods to restrict the intake of carotenoid containing food

Participants consume a basal diet low in natural carotenoids throughout the 4 days trial period of each week( Monday to Thursday) and on test days consume one of the 4 test foods (carrot soup). There are 2 control days and 2 test food days on 2 consecutive weeks Participants are required to follow the low carotenoid basal diet for a period of 4 days each week for 2 consecutive weeks. This diet is supplied by CSIRO from specially selected foods to restrict the intake of carotenoid containing foods such as carrots, oranges and tomatoes to a daily dose of <650ug. For each of the test foods the participants will be required to eat a single 300mL serve of the carrot soup containing ~15 mg carotenoids along with 2 slices of white bread and 10g of butter. There will be a 3 day wash-out period between trial periods (from Friday one week to Monday the following week). In each week each participant would randomly have 2 of the test foods on any of the 4 days within that week. The remaining 2 days are control days during which the participants consume only the basal diet with low carotenoids as supplied by CSIRO. During the following week the participants would be required to have the remaining 2 test foods on randomly selected days with the 2 remaining days being control days as described above.

Sponsors

Food Futures Flagship- Nutrient release and Bioavailability Stream
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
20 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

conventional and well-functioning permanent ileostomy

Exclusion criteria

Use of any form of drug therapy or medication or supplements that may interfere with bowel function eg antibiotics Definite or suspected personal history or family history of adverse events or intolerance of plant-based foods being tested in this study Persons considered by the investigator to be unwilling, unlikely or unable to comprehend or comply withthe study protocol and restrictions Persons unwilling or unable to collect ileal effluent as required Paticipants taking any supplements which could interfere with study parameters

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026