None listed
Conditions
Brief summary
The prospect of surviving cancer has improved over the past two decades and strategies to enhance survival are now a priority of research. This research aims to investigate the possible deleterious effects of high dose chemotherapy (HDC) and autologous stem cell transplants (ASCT), and assess the efficacy of a home-based physical activity program implemented during treatment in patients with lymphoma treated with HDC and ASCT, on the physiological and psychosocial outcomes that can possibly negatively impact the health status of patients. Outcome measures will include aerobic fitness, body composition, quality of life, blood markers, strength, physical activity levels, fatigue and symptom distress, which are currently not well understood in this population. Aims; 1. To assess the level of physiological and psychosocial deterioration up to three months post-chemotherapy as a result of HDC and ASCT as treatment for lymphoma. 2. To assess the efficacy of a home-based physical activity program completed during treatment compared to waitlisted participants on physiological and psychosocial deterioration as a result of HDC and ASCT as treatment for lymphoma. 3. To provide guidelines for future exercise interventions in patients with lymphoma treated with HDC and ASCT.
Interventions
Participants assigned to the exercise group will be required to complete three sessions per week of home-based physical activity for the duration of their treatment. Participants treatment duration will be determined by medical staff as treatment progresses, and is not altered by participation in this study. Prescription of the physical activity program will be implemented in accordance with the special precautions for cancer populations. Patients will be supervised for up to 3 weeks by an Exerc
Participants assigned to the exercise group will be required to complete three sessions per week of home-based physical activity for the duration of their treatment. Participants treatment duration will be determined by medical staff as treatment progresses, and is not altered by participation in this study. Prescription of the physical activity program will be implemented in accordance with the special precautions for cancer populations. Patients will be supervised for up to 3 weeks by an Exercise Physiologists to ensure correct exercise technique and intensity are achieved. Following this, patients will complete the final weeks of home-based physical activity on their own with reference to exercise booklets and DVDs, plus follow-up weekly phone calls and occasional visits during the intervention. A second group of participants will be placed on a waitlist and will complete the same home-based physical activity program following treatment.
Sponsors
University of Western Australia
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Patients diagnosed with a haematological malignancy, scheduled for high-dose chemotherapy and autologous stem cell transplant, receive doctors consent, able to provide written consent,
Exclusion criteria
a) a pre-existing cardiac disease or uncontrolled hypertension b) less than 18 years of age or older than 70 c) unable to participate in a 12 week structured exercise d) unable to understand the implications of participation in the trial e) currently engaged in a structured exercise programme f) have undergone recent surgery which limits their ability to participate in exercise g) do not pass the Revised Physical Activity Readiness Questionnaire (r-PARQ).
Outcome results
None listed