Preoperative oral paracetamol versus intraoperative intravenous paracetamol: plasma levels in the recovery room

Does giving paracetamol intravenously during an operation result in significantly higher plasma paracetamol levels in the early postoperative period than giving the same dose orally as a premedicant?

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000908235

Enrollment

Registered

2009-10-20

Start date

2009-01-08

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Paracetamol is traditionally given by anaesthetists in tablet form around one hour before an operation with the intention of providing good pain relief in the period following the operation. Recently, an IV formulation has become available and can be given during the operation. We compared which of these techniques gave higher levels of paracetamol in the bloodstream after the operation. We also looked at how much extra pain relief was needed in the recovery room, how long patients stayed in the recovery room and how sore they were.

Interventions

1 g intravenous (IV) paracetamol given intraoperatively

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Day case arthroscopies Suitable for laryngeal mask anaesthesia American Society of Anaesthesiologists (ASA) 1 & 2 Body mass index (BMI) less than 35

Exclusion criteria

Contraindication to paracetamol BMI over 35 Requiring intubation rather than laryngeal mask airway (LMA) use Requiring any other intraoperative analgesics other than IV fentanyl

Outcome results