How does the anti-sickness drug dexamethasone influence the immune function in healthy volunteers?

The influence of antiemetic doses of dexamethasone on lymphocyte sub-populations in healthy volunteers.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000903280

Enrollment

Registered

2009-10-19

Start date

2009-06-08

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Dexamethasone is a drug commonly given to prevent postoperative nausea and vomiting. It also has properties that dampen the body's immune response to infection. In this study, we propose to examine healthy volunteers who were either given placebo or dexamethasone in 2mg, 4mg or 8 mg. Blood samples were taken before and after the intervention to determine the effect that they have on the immune system.

Interventions

Single dose dexamethasone 2mg.4mg or 8 mg in 50 mls of normal saline infused over 15 minutes in healthy volunteers

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy volunteers in American Society of Anaesthesiologists Classification (ASA) I-II

Exclusion criteria

1.Current drug therapy with antiemetics, steroids or serotonergic antidepressants 2.Active infection known or suspected metastatic disease 3.Previous chemotherapy treatment 4.Allergy/intolerance to any of the study drugs (including renal or hepatic impairment, active peptic ulcer disease, ischaemic heart disease, QT prolongation, major psychiatric illness) 5.Diabetes mellitus or history of seizures 6.Participation in any other research trial 7.Pregnant or possibility of

Outcome results