None listed
Conditions
Brief summary
This is a prospective cohort single centre study, examining the relationship between serum levels of Cystatin C and Procalcitonin, and post-operative adverse outcomes in high risk cardiac surgery patients.
Interventions
Each patient who meets the inclusion criteria for the study will have a blood test taken. The blood will be taken from either an existing intervenous device or from a vein in the patients arm. Blood will be taken pre surgery and then on days 0(post operative), 1, 3 and 5 we are looking at Cystatin C and Procalcitonin levels.
Sponsors
Prince of Wales Hospital
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
The patient is undergoing on pump Coronary artery bypass grafting, valve or combination surgery, Age > 18 years, Willingness to give written informed consent and willingness to participate in and Comply with the study,The patient fulfils ONE of the following criteria: Age > 70 years Glomerular Filtration Rate < 60 History of Diabetes (noninsulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus) Documented left ventricular ejection fraction < 45% Anticipated complex cardiac surgery (Combined Coronary artery bypass grafting-valve, > 1 valve or aortic root surgery)
Exclusion criteria
The patient is receiving long term corticosteroid or immune suppressive therapy, History of Thyroid Disease, Undergoing salvage surgery,The patient has a history of a condition or psychological illness as to interfere with the patient’s ability to understand the requirements of the study, The patient receives dialysis for pre-existing Chronic Renal Failure,The patient is a renal transplant recipient,The patient is known to be pregnant
Outcome results
None listed