None listed
Conditions
Brief summary
The purpose of the study is to formally assess the impact of fibre alone on insulin sensitivity, and if this is achieved independently of weight loss. Fibre will be givenas a supplement, without altering other aspects of the diet. The hypothesis is that the properties of fibre can benefit insulin senstivity independently of weight loss, clarifying its role in dietary interventions for overweight, and normal weight insulin resistant people. We expect the effect to be greatest in the obese population.
Interventions
Participants will be randomized to recieve 6g per day psyllium or 6g/d potato starch placebo for 6 weeks on each intervention. Psyllium and placebo will be given as 6g/day as 12 x 500mg capsules, with participants instructed to consume these at once or in divided doses with a large glass of water. After 6 weeks participants will washout for 2 weeks before starting 6 weeks on the opposite intervention.
Sponsors
University of Auckland / Liggins Institute
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
Male
Age
15 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
15 - 16 year old males from low socio-economic areas.
Exclusion criteria
Receiving medications that influence insulin sensitivity (SI) (incluing oral steroids and metformin). Genetic conditions, (Turner, Downs or Prader-Willi syndrome). Coeliac disease or other malabsorption disorders.
Outcome results
None listed