The Influence of Kidney Graft Function on Beat-to-beat QT Interval Variability

The Influence of Kidney Graft Function on Beat-to-beat QT Interval Variability in Kidney transplant recipients at 1 year post-transplant

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12609000878279

Enrollment

Registered

2006-03-31

Start date

2005-06-01

Completion date

2006-12-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

It is hypothesized that renal transplant recipients with renal graft dysfunction are prone to cardiac arrhythmia's and sudden death secondary to changes in cardiac structure and function.

Interventions

Observational study of the beat to beat QT interval variability assessed continuously for 5 minutes in standard 12-lead ECG, single echocardiographic measurement of the left ventricular mass and estimation of renal graft function at 1 year post-transplant

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

Kidney transplant recipients at 1 year post-transplant. Stable sinus rhythm with normal atrioventricular conduction on standard electrocardiogram (ECG). Absence of heart failure symptoms and signs.

Exclusion criteria

Patients receiving any drugs that are known to influence the QT interval duration. Clinical, ECG, and echocardiographic evidence of coronary artery disease. Patients with diabetes mellitus. Increment of serum creatinine >= 20% at any time during the preceding three months.

Outcome results