Magnesium bicarbonate supplemented spring water in postmenopausal women

Double-blind, placebo-controlled outpatient study of the effects of specific alkaline magnesium bicarbonate solutions on biomarkers of acid/base balance, calcium metabolism and cardiovascular risk factors in postmenopausal volunteer women

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000863235

Enrollment

Registered

2009-10-06

Start date

2005-08-31

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The study aimed to compare changes in various blood and urine markers of bone metabolism and inflammation in post-menopausal women drinking magnesium bicarbonate supplemented spring water or spring water without supplements. Additionally, the following other factors were investigated for change between treatment groups and general safety 1.venous blood pH 2.urine pH 3.blood pressure 4.serum lipids 5.serum biochemistry 6.haematology 7.urinalysis

Interventions

Magnesium bicarbonate supplemented spring water: 650 mg/L bicarbonate, 120 mg/L magnesium at pH 8.3 to 8.5. Daily intake 1500-1800 mls equals 975-1170 mg bicarbonate, 180-216 mg magnesium. Subjects consumed the water for 84 days.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

50 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Heatlhy postmenopausal females, 50-70 years, body mass index (BMI) 20-35kg/m2

Exclusion criteria

Excluded if serious health issues or major laboratory abnormalities. Restrictions were placed on concomitant medications containing calcium and magnesium, diuretics and antacids. Restrictions were placed on major lifestyle modifications during the study period.

Outcome results