A clinical study in healthy volunteers to determine whether orally consumed tocopheryl phosphates are incorporated into oil produced/secreted by the skin.

A clinical study in healthy volunteers to determine whether orally consumed tocopheryl phosphates are incorporated into secreted sebum

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000848202

Enrollment

Registered

2009-09-30

Start date

2010-10-26

Completion date

2012-08-03

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Alpha-tocopherol plays an important role in preserving skin barrier function; it is concentrated in sebum and secreted to the skin in high concentrations. It is not known whether supplemented tocopheryl phosphates, which have been shown to play a protective role in prevention of UV damage, follow a similar metabolic pathway to the skin surface as alpha-tocopherol.

Interventions

Mixed tocopheryl phosphates (TPM) capsules at approx. 400 International Units (IU) (~316 mg) to be taken once a day (after breakfast, between 7 am and 9 am), for 28 days.

Study design

Allocation

Randomised controlled trial

Primary purpose

Educational / counselling / training

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

- Provision of written informed consent. - "Healthy" male or female. - At least 18 years old. - Fitzpatrick skin types II or III.

Exclusion criteria

- Pregnant or breastfeeding. - History of dermatological disorders. - Current medical problems or systemic medication. - Oral or topical anti-oxidant supplementation within 14 days of baseline. - Smokers. - Exposure to intense solar or artificial UV/ tanning salons in the 3 months prior to baseline. - Unable or unwilling to use Vitamin E free skin care products for the duration of the trial. - Taking warfarin or blood thinning medications. - Dependent on iron supplements. - Diabetes, hyperthyroidism, or heart disease. - Unwilling or unable to avoid ultraviolet (UV) exposure for the duration of the trial.

Outcome results