Identification of Predictive and Prognostic Factors in Malignant Pleural Mesothelioma

For the retrospective part, the following variables will be observed: - immunohistochemical (IHC) staining of the archival tumour tissues - micro Ribonucleic acid (miRNA) expression of the tumour tissues For the prospective part, the following variables will be observed: - clinical/demographic details at baseline only - IHC staining of the tumour at baseline only - miRNA of the tumour at baseline only - Quality of life (QoL) data at baseline then at regular intervals depending on therapy prescribed by treating physician - blood tests including full blood counts, electrolytes, renal function and liver function at baseline then at regular intervals depending on therapy prescribed by treating physician - inflammatory markers + cytokines at baseline then at regular intervals depending on therapy prescribed by treating physician - plasma proteomic at baseline then at regular intervals depending on therapy prescribed by treating physician - nutritional assessment at baseline then at regular intervals depending on therapy prescribed by treating physician - Computed Tomography (CT) scan at baseline, after 4 cycles of chemotherapy, at completion of chemotherapy and then at physician's discretion.