None listed
Conditions
Brief summary
Purpose of the study is to examine mother and baby outcomes following exposure to antidepressant medication during pergnancy. Patients will be asked to either continue antidepressant medication up until and after delivery; or to wean medication at 35 weeks of pregnancy and recommence at one week post partum. The primary hypothesis is the women who continue their medication through delivery will have fewer depressive symptoms. The secondary hypothesis is that babies exposed to antidepressant medication to term will be more likely to have discontinuation symptoms such as jitteriness and irritability
Interventions
The intervention group will wean antidepressnt medication between 35 and 37 weeks of pregnancy, and then restart at one week post partum. The medications given will be any SSRI/SNRI medications given orally at dosage equivalents of up to 60mg of citalopram daily or 375mg of Venlafaxine daily. In many cases the participants will already be on the medications prior to being enrolled in the trial. In the group that weans they will continue their medication on a daily basis for as long as clinica
The intervention group will wean antidepressnt medication between 35 and 37 weeks of pregnancy, and then restart at one week post partum. The medications given will be any SSRI/SNRI medications given orally at dosage equivalents of up to 60mg of citalopram daily or 375mg of Venlafaxine daily. In many cases the participants will already be on the medications prior to being enrolled in the trial. In the group that weans they will continue their medication on a daily basis for as long as clinically indicated; usually at least twelve months post partum
Sponsors
Royal Brisbane Hospital
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Pregnant, on SSRI/SNRI medications
Exclusion criteria
Comorbid substance abuse, use of benzodiazepines, and history of or current suicidality
Outcome results
None listed