None listed
Conditions
Brief summary
Biobrane is our gold standard for superficial partial thickness burns. AWBAT is very similar but adheres more rapidly to the wound. This is the rate limiting step in healing and allowing theses patients to be treated as outpatients. The study aims to compare the two in rate of epithelialisation and pain perception (the other issue which keeps burn patients in hospital).
Interventions
AWBAT is a second generation temporary epidermal replacement. It is to be compared with Biobrane (a first generation product with the same indications). Both materials are applied to meticulously cleaned superficial partial thickness burns under general anaesthesia in theatre. The piorcine peptide component in the materials stimulates the conversion of fibrinogen in the burn exudate to fibrin, firmly adhering the material to the burn. Both materials then stay in-situ until the burn re-epithelial
AWBAT is a second generation temporary epidermal replacement. It is to be compared with Biobrane (a first generation product with the same indications). Both materials are applied to meticulously cleaned superficial partial thickness burns under general anaesthesia in theatre. The piorcine peptide component in the materials stimulates the conversion of fibrinogen in the burn exudate to fibrin, firmly adhering the material to the burn. Both materials then stay in-situ until the burn re-epithelialises beneath. Both materials then spontaneously separate. The length of material adherence depends on the burn depth - very superficial 4-5 days, mid-dermal up to 14 days. All participants will receive both Biobrane and AWBAT thus acting as their own controls since Biobrane is the material we currently use routinely according to our surgical protocols.
Sponsors
Royal Adelaide Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Superficial partial thickness burns Two non-contiguous burn sites of the same approximate size/depth for comparison, OR One burn site large enough to accommodate both a 6” square AWBAT (Trademark) dressing AND a 6” square Biobrane (Registered Trademerk) dressing Burn wounds ranging between 2% < Total Body Surface Area <40%
Exclusion criteria
Delayed presentation (>48 hours) Ventilator dependence Signs of burn wound infection Pregnancy/Lactation Electrical, chemical or frostbite injury Non-English speakers (from an informed consent perspective) Patient from a rural centre where there is a burns link-nurse (Port Pirie, Mount Gambier, Adelaide Hills, Gawler) Co-morbidity which may compromise healing Known allergy to porcine products
Outcome results
None listed