Protecting the lungs in patients undergoing lung transplantation.

Does remote ischaemic post-conditioning reduce ischaemia reperfusion injury in patients undergoing lung transplantation?

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000763246

Enrollment

Registered

2009-09-02

Start date

2009-12-28

Completion date

2013-09-27

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Randomised controlled trial to test if short periods of lack of blood flow to the leg can improve the function of new lungs in lung transplantation.

Interventions

Normal best standard practice with remote ischaemic post-conditioning using 3 cycles of transient leg ischaemia and reperfusion (5 min ischaemia followed by 5 min reperfusion, 3 times) using a thigh tourniquet at least 5 min prior to donor lung reperfusion. Total stimulus 30 minutes prior to reperfusion.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

All patients listed for lung transplantation (single or double) by the Alfred Hospital lung transplant service.

Exclusion criteria

Patients treated with sulphonylureas (oral hypoglycaemic agent). Planned use cardiopulmonary bypass. Planned combined heart-lung transplantation.

Outcome results