None listed
Conditions
Brief summary
Many articles have suggested that ESD is a safe and effective alternative treatment for early gastric cancer. But there is still no one,which is prospective randomised controlled , to compare ESD and laparotomy for early gastric cancer . So our purpose is to compare esd and laparotomy for early gastric cancer in a prospective randomised controlled way.
Interventions
Endoscopic submucosal dissection (ESD) is an advanced technique of therapeutic endoscopy for superficial gastrointestinal neoplasms. Three steps characterize it:injecting fluid (several fluids such as saline, glycerol and hyaluronic acid are usually combined with diluted epinephrine) into the submucosa to elevate the lesion,cutting the surrounding mucosa of the lesion, and dissecting the submucosa beneath the lesion.
The amout of fluid varies according to the size of cancer and the amount is
Endoscopic submucosal dissection (ESD) is an advanced technique of therapeutic endoscopy for superficial gastrointestinal neoplasms. Three steps characterize it:injecting fluid (several fluids such as saline, glycerol and hyaluronic acid are usually combined with diluted epinephrine) into the submucosa to elevate the lesion,cutting the surrounding mucosa of the lesion, and dissecting the submucosa beneath the lesion. The amout of fluid varies according to the size of cancer and the amount is appropriate when the fluid injected can make the cancer safe enough for endoscopists to cut it off. This is a one-off treatment and the duration of ESD itself often varies from one hour to 3 hours.
Sponsors
Linghu Enqiang
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
1.early gastric cancer diagnosed by both gastroscopy and pathological examination. 2.lesion to be mucosal or submucosal by endoscopic ultrasound( EUS).
Exclusion criteria
1.remote metastasis by computed tomography(CT),magnetic resonance imaging(MRI) or positron emission tomography (PET). 2.undifferentiated carcinoma,signet-ring cell carcinoma 3.after treatment of endoscopic electrocoagulation,laser,Argon gas,microwave,endoscopic mucosal resection(EMR) or repeated biopsy in the same lesion.
Outcome results
None listed