None listed
Conditions
Brief summary
I am aiming to minimise the low blood pressure and worsening of heart function caused by anaesthetic drugs during this procedure (TOE Cardioversion) by combining 2 different anaesthetic drugs.
Interventions
Propofol and ketamine for sedation for Tranoesophageal Echocardiography followed by Cardioversion (TOE cardioversion).
1/ propofol 200mg and ketamine 40mg will be combined in the same syringe (propofol 10mg/ml, ketamine 2mg/ml). After 25mcg of fentanyl intravenously (IV) 2-4mL boluses of the drug combination will be administered intravenously (IV) every 15-30 seconds according to clinical response. Treatment in this method will be continued until sucessful cardioversion or abandoning of the pr
Propofol and ketamine for sedation for Tranoesophageal Echocardiography followed by Cardioversion (TOE cardioversion). 1/ propofol 200mg and ketamine 40mg will be combined in the same syringe (propofol 10mg/ml, ketamine 2mg/ml). After 25mcg of fentanyl intravenously (IV) 2-4mL boluses of the drug combination will be administered intravenously (IV) every 15-30 seconds according to clinical response. Treatment in this method will be continued until sucessful cardioversion or abandoning of the procedure as decided by the treating cardiologist. 2/ Cardioversion will be external with pads placed by the cardiologist, usually antero-posterior (AP) positioning is used. A single episode of care (with number of attempts at cardioversion determined by patient response) will be studied.
Sponsors
fremantle hospital (bequest - deceased estate ex-surgeon)
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Atrial fibrillation booked for TOE followed by cardioversion
Exclusion criteria
allergy, psychosis, planned genaral anaesthesia with intubation
Outcome results
None listed