Randomised, Placebo Controlled Trial of Ropivocain Wound Infusion in Laparoscopic Colonic Resection

Do patients who undergo laparoscopic colonic resections who receive ropivocain wound infusions, compared to normal saline infusions have better postoperative pain relief with reduced requirements for opioids.

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000745246

Enrollment

Registered

2009-08-27

Start date

2007-01-31

Completion date

2009-12-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is to determine if the use of local anaesthetic infusion into the surgical incision is effective in reducing pain following laparoscopic (keyhole) colonic resections (removal of sections of large bowel). It difficult to predict the outcome of this paper as laparoscopic surgery uses only small incisions which will generate a smaller proportion of the total postoperative pain felt compared to the pain generated from the intraabdominal surgical site which has not been altered through this technique.

Interventions

Ropivocain (a form of local anaesthetic) infusion (10mL/hr) at the surgical incision site using fine bore catheter inserted at the time of wound closure. Infusion commences upon application of the wound dressings and continues until postoperative day 3. At this time the catheter is to be removed by nursing staff on the ward 72 hours after the infusion started. Laparoscopic procedures are best known as keyhole procedures and involve using long instruments to manipulate the organs within the abdomen through very small incisions. Colonic resection refers to the removal of a part of the large bowel for a variety of indications although the most common indications are sepsis due to local perforation and malignancy.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

all patients booked for elective laparoscopic colonic resection over the age of 18 who are able to give informed consent

Exclusion criteria

renal failure chronic pain syndromes or already on long term analgesia, regardless of indication urgent or emergency procedures

Outcome results