Tropisetron versus metoclopramide for nausea and vomiting in the emergency department: a randomised, double blinded, clinical trial

A randomised double blind clinical trial to compare the efficacy of tropisetron and metoclopramide in decreasing nausea and vomiting in the emergency department

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000733279

Enrollment

100

Registered

2009-08-25

Start date

2009-10-26

Completion date

2010-03-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Tropisetron has been shown to be more efficacious than metioclopramide in the post-operative and chemotherapy settings. Both drugs are widely used in the emergency department setting. However, no study has been undertaken to compare the drugs in the emergency department setting.

Interventions

An intravenous bolus of 5mg of tropisetron (over 30 seconds)

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients who have presented to the emergency department for treatment; age 18 years or more; nausea and/or vomiting that requires drug treatment as determined by the treating physician

Exclusion criteria

Refusal to participate; Migraine (metoclopramide sedation confers an advantage); Inability to co-operate or consent due to debility, significant illness, language barriers, altered consciousness (as determined by the emergency department or study staff); Known allergy or hypersensitivity to tropisetron or metoclopramide; Intoxication (alcohol, substance abuse); Pregnancy; Previous administration of antiemetic within 24 hours

Outcome results