None listed
Conditions
Brief summary
We could not find any study that has examined the use of Garlic (Allium sativum, garlick) to treat tuberculosis as add on to antituberculosis regimen or to prevent drug induced hepatitis. It has been reported byGholami et al (pharmacy practice, 2006, 4(3): 134) that Antituberculosis -induced Hepatotoxicity in our region is much higher than western countries (25.9% vs 4.5%) . The proposed study will provide scientifically valid data to date on whether garlic is effective in preventing hepatitis induced by anti tuberculosis regimen or not..
Interventions
There are 2 treatment arms:
Randomised allocation to Garcin (1000mg).
Dosage - 2 tablets per day will be administered orally for the first 2 weeks of the standard antituberculosis regimen.
Sponsors
Masih Daneshvari Hospital, National Research Institute of Tuberculosis and Lung Diseases (NRITLD)
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Patients newly diagnosed with smear positive pulmonary tuberculosis admitted to the hospital who receive standard treatment
Exclusion criteria
Human Immune Deficiency Virus (HIV) positives, confirmed hepatitis at baseline, patients with cirrhosis, renal failure, and known hypersensitivity to garlic, those prone to hemorrhage, and hypotension
Outcome results
None listed