None listed
Conditions
Brief summary
This study is designed to look at the effects of weight reduction surgery on gut hormones, in particular how different types of surgery may have different effects on gut hormones. These differences may therefore be related to how resolution of diabetes occurs after surgery that occurs before any weight loss occurs. Continuous glucose monitoring during the operation and immediately after may also be related to the changes in gut hormones that we are studying. This would allow more in depth understanding of the mechanism of diabetes resolution after weight reduction surgery. We would also like to study how risk factors for vascular disease may change after the two different bariatric surgery (gastric sleeve resection and gastric bypass surgery), and this is done by various blood tests as well as scans to look at structure and function of the heart.
Interventions
patients with type2 diabetes and obesity undergoing gastric sleeve resection and gastric bypass bariatric surgery. This is a prospective study where observation will be made on 2 groups of patients: (1) those scheduled for gastric sleeve resection surgery (2)those scheduled for gastric bypass bariatric surgery.
gastric sleeve resection is carried out by a one off laparoscopic technique of about 90minutes. under general anaethesia.
gastric bypass is also performed laparoscopically which takes a
patients with type2 diabetes and obesity undergoing gastric sleeve resection and gastric bypass bariatric surgery. This is a prospective study where observation will be made on 2 groups of patients: (1) those scheduled for gastric sleeve resection surgery (2)those scheduled for gastric bypass bariatric surgery. gastric sleeve resection is carried out by a one off laparoscopic technique of about 90minutes. under general anaethesia. gastric bypass is also performed laparoscopically which takes about 120-150minutes. under general anaethesia. Comparison will be made with control group (patients scheduled for elective laparoscopic cholecystectomy) observation period until 6 months post surgery
Sponsors
University of Auckland
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Inclusion criteria: 1. patients with type 2 diabetes or impaired glucose tolerance planned to have gastric bypass surgery at Auckland hospital 2. patients with type 2 diabetes or impaired glucose tolerance planned to have gastric sleeve resection at Middlemore hospital 3. Patients with type 2 diabetes or impaired glucose tolerance planned to have elective laparoscopic cholecystectomy (will required to be matched for BMI and age for cases in study)
Exclusion criteria
Exclusion criteria: 1. Age <18, or >70 2. BMI < 35 kg/m2 3. Cardiovascular conditions including significant coronary artery disease, congestive heart failure 4. Severe pulmonary disease 5. Previous bariatric/gastric/small bowel operation. 6. Underlying endocrinology disorder or genetic syndrome related to obesity and secondary diabetes. 7. Steroid dependence 8. Exenatide treatment within 3 months of surgery 9. Previous surgery to pancreas, or other pancreatic pathology 10. Pregnant women
Outcome results
None listed