Skin changes related to insulin therapy in type 1 diabetes

Conditions

None listed

Brief summary

Skin changes such as lipohypertrophy and lipoatrophy affect around 20% of patients with Type 1 Diabetes Mellitus during the course of their illness. There has been very liitle previous research in this area. Little is know about the psychological impact of these changes, the pathophysiology of the changes, or the best treatment. The aim of this study is 1) to investigate clinical, immunological and allergic factors that may be associated with these skin changes, 2) examine the histology of the skin (ie look at the structure of the skin under the microscope) and cells involved in lipodystrophic skin

Related papers

No related papers found yet.

Interventions

Prospective observational study of skin changes related to insulin therapy. Patients will be seen at their routine 3 monthly clinic appointment. All patients will be invited to participate and have thier clinical risk factors assessed and invited to have a skin biopsy and intradermal tesing performed. Those with skin changes will have their clinical risk factors assessed, be asked to complete a short questionnaire about the impact that these skin changes have on their diabetes self manageemnt, a

Prospective observational study of skin changes related to insulin therapy. Patients will be seen at their routine 3 monthly clinic appointment. All patients will be invited to participate and have thier clinical risk factors assessed and invited to have a skin biopsy and intradermal tesing performed. Those with skin changes will have their clinical risk factors assessed, be asked to complete a short questionnaire about the impact that these skin changes have on their diabetes self manageemnt, and invited to have their skin changes photographed, a skin biopsy taken, intradermal skin testing, and patch testing. This is not an interventional trial.

Eligibility

Sex/Gender

All

Age

5 Years to 60 Years

Healthy volunteers

No

Inclusion criteria

known type 1 or 2 diabetes understand the research protocol consent

Exclusion criteria

moderate-severe eczema or other skin condition,

Outcome results