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Sedentary behaviour and metabolic risk

The acute effects of a single bout of prolonged sitting on postprandial glucose and lipid metabolism, with and without intermittent bouts of light-intensity or moderate-intensity activity in older overweight adults.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12609000656235
Acronym
IDLE (Intensity Defined Little Exercise) breaks study
Enrollment
22
Registered
2009-08-04
Start date
2009-04-02
Completion date
2010-08-12
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

It is well known that being physically active is important for maintaining good health. However, new evidence has emerged showing that being sedentary (sitting for prolonged periods) is associated with indicators of poor health, such as elevated blood glucose and blood fats. Importantly, it appears that the effects of sedentary behaviour are independent of a person’s physical activity level. This suggests that each should be looked upon as being separate behaviours, meaning that a person could engage in appropriate physical activity (30 minutes of daily activity), yet spend many hours for the rest of the day being sedentary, such as at an office desk. More recently, data from observational research (AusDiab) indicates people who break up their sitting time throughout the day with light-intensity activity (such as light walking) may have better blood glucose and blood fat levels than people who sit for prolonged periods without activity breaks. The implications of these findings are that lifestyle strategies to reduce the risk of developing diabetes and cardiovascular disease may need to also focus on reducing sedentary time through regular activity breaks, in addition to the promotion of regular physical activity. However, before such intervention strategies can be developed and tested, we need to understand the short-term effects of being sedentary (sitting) on blood glucose and blood fats within a well-designed experimental trial. Therefore, this study aims to examine the short-term effects of prolonged sitting with and without intermittent activity bouts. The study will provide information that will assist in the design, implementation and evaluation of strategies that target reducing sedentary behaviour in older, overweight adults.

Interventions

This randomised crossover trial involves three single-day treatment conditions, each separated by a one-week wash out period Intervention 1: One day (total duration=7 hours) of prolonged sitting with intermittent light-intensity activity breaks. Participants will remain seated for the initial 140mins (steady-state) period, after which they will complete a 2 min bout of light-intensity walking activity on a treadmill (level, firm surface, slow pace - 3.2km/hr). Participants will then return to t

This randomised crossover trial involves three single-day treatment conditions, each separated by a one-week wash out period Intervention 1: One day (total duration=7 hours) of prolonged sitting with intermittent light-intensity activity breaks. Participants will remain seated for the initial 140mins (steady-state) period, after which they will complete a 2 min bout of light-intensity walking activity on a treadmill (level, firm surface, slow pace - 3.2km/hr). Participants will then return to the seated position. The light-intensity walking breaks will be repeated on another 13 occasions every 20 mins during a 7 hour period (total walking time=28mins). Intervention 2: One day (total duration= 7 hours) of prolonged sitting with intermittent moderate-intensity activity breaks. Participants will remain seated for the initial 140mins (steady-state) period, after which they will complete a 2 min bout of moderate-intensity walking activity on a treadmill (level, firm surface, slow pace - 3.2km/hr). Participants will then return to the seated position. The moderate-intensity walking breaks will be repeated on another 13 occasions every 20 mins (total walking time=28mins).

Sponsors

Baker IDI Heart and Diabetes Institute
Lead SponsorCharities/Societies/Foundations

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
45 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

Inclusion criteria includes: overweight or obesity (body mass index (BMI) > 25 kg/m2 but = 45 kg/m2), and; impaired fasting glucose; impaired glucose tolerance; or established diet-only treated type 2 diabetes.

Exclusion criteria

Exclusion is based on: pregnancy; employment in a non-sedentary occupation; currently watching < 3 hours of television per day; regularly engaged in moderate-intensity exercise = 150min/week (‘sufficiently active’) for 3 months; diabetes; use of lipid lowering medications; known physical activity contraindications, major illness/injury (acute or chronic) or physical problems that may limit the ability to perform the necessary.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 20, 2026