None listed
Conditions
Brief summary
Sports anti-doping study. The aim of this study is to see what effect injections of a synthetic hormone called a GnRH analog have on testosterone levels as measured in blood and urine samples. GnRH analogs are banned in elite sports as they are considered to enhance an athletes performance by increasing the body's production of testosterone. In this study blood and urine samples will be collected from healthy male volunteers before and after several injections of Lucrin (GnRH anaolg). Half of the volunteers (8) will be randomly assigned to also receive 2 injections of a drug called nandrolone decanoate. It is thought that nandrolone and GnRH analogs may be used in combination for ilicit sports doping.
Interventions
Participants will be randomised to one of two groups.
Group 1 will receive daily subcutaneous injections of Lucrin 1mg for 4 days in week 1 (days 1 to 4) and again for 4 days in week 3 (days 15 to 18).
Group 2 will also receive daily subcutaneous injections of Lucirn 1mg for 4 days in week 1 (days 1 to 4) and again for 4 days in week 3 (days 15 to 18) as well as an intramuscular injection of nandrolone decanoate on day 12 (200mg) and day 17 (100mg).
Blood an urine samples will be collected eac
Participants will be randomised to one of two groups. Group 1 will receive daily subcutaneous injections of Lucrin 1mg for 4 days in week 1 (days 1 to 4) and again for 4 days in week 3 (days 15 to 18). Group 2 will also receive daily subcutaneous injections of Lucirn 1mg for 4 days in week 1 (days 1 to 4) and again for 4 days in week 3 (days 15 to 18) as well as an intramuscular injection of nandrolone decanoate on day 12 (200mg) and day 17 (100mg). Blood an urine samples will be collected each morning (except at weekends) from day 1 to day 24. The overall duration of treatment is 24 days.
Sponsors
Sydney South West Area Health Authority (SSWAHS)
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy men aged 18 to 50.
Exclusion criteria
Recent history of steroid use/abuse
Outcome results
None listed