None listed
Conditions
Brief summary
Parkinson's disease can cause cognitive decline. Although the exact cause of neuronal loss in Parkinson's disease remains unknown, current evidence points to the presence of ongoing oxidative stress. The physical exercise can benefit the cognitive function in older people with Parkinson's disease. Ginkgo biloba and omega-3 has been reported to be an antioxidative agent and neuroprotective. We suspect that the combination of the three may potentiate the effect.
Interventions
Extract of Ginkgo biloba, omega-3, physical exercise.
All these interventions will be combined together for the treatment group.
The amount of Gingko biloba and omega-3 to be used, respectively, 80mg and 1g per day in capsules, during six months.
The exercise will envolve coordination, balance, flexibility, strength and aerobic endurance, one hour for sessions, three times a week, during six months.
Sponsors
Universidade Federal de Sao Paulo
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Age 60 or older; present clinical diagnosis of Parkinson's disease in the stages from 1 (mild) to 3 (moderate) assessed by the Hoehn and Yahr Scale;not present indication of dementia by results of the Mini-Mental State Examination—MMSE;not be attending any physical exercise program.
Exclusion criteria
Those who not meet the criteria for inclusion; show allergic reaction to substances and not reach 70% of attendance in training.
Outcome results
None listed