Is there a relationship between sensitivity to fat in the mouth and gastrointestinal tract, and is sensitivity to fat different in obesity?

A comparison of antropyloroduodenal motility, hormone release, appetite and energy intake after a 90 minute infusion of fat versus saline in lean and obese males

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12609000557235

Enrollment

Registered

2009-07-08

Start date

2009-02-02

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary purpose of the study was to investigate gastrointestinal and taste sensitivity to fats, and determine if 1) obese and lean individuals differed in their responses to an intraduodenal infusion of fat or saline and if their taste sensitivity to fats were also different, and 2) determine if taste and gastrointestinal fat sensitivity were related.

Interventions

Subjects received a 90 minute intraduodenal infusion of fat (C18:1) delivered at 0.78kcal per minute (70Kj total) and saline, at a rate of 2ml/ min (180ml total). Treatments were separated by 3-14 days, and all subjects received both treatments.

Study design

Allocation

Randomised controlled trial

Intervention model

Single group

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

Male

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

Subjects had to be males between the ages of 18 -55 years, with a body mass index (BMI) between 18 -35 kg/m2). Subjects were required to be unrestrained eaters, consume less than 20g of alcohol per week, be non-smokers, free of gastrointestinal or chronic disease and not currently taking medication whicfunction.

Exclusion criteria

Restrained eaters, smokers, sufferers of gastrointestinal or chronic disease, individuals currently on medication known to affect appetite or gastrointestinal function. Subjects completed factor 1 of the 3 factor eating questionnaire (restrained eaters are defined as those who score higher than 12), subjects were asked about their personal and familial medical history relating to chronic illness (heart disease and cancer) as well as gastrointestinal disease, ie Crohns, Irritable Bowel Syndrome. Subjects were asked if they were smokers, and how much alcohol they consumed on a weekly basis.

Outcome results